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Background: A treatment algorithm and screening examination have been developed to guide patient management and prospectively determine potential for highly active individuals to succeed with nonoperative care after anterior cruciate ligament rupture.
Objective: To prospectively characterize and classify the entire population of highly active individuals over a 10-year period and provide final outcomes for individuals who elected nonoperative care.
Methods: Inclusion criteria included presentation within 7 months of the index injury and an International Knee Documentation Committee level I or II activity level before injury. Concomitant injury, unresolved impairments, and a screening examination were used as criteria to guide management and classify individuals as noncopers (poor potential) or potential copers (good potential) for nonoperative care.
Results: A total of 832 highly active patients with subacute anterior cruciate ligament tears were seen over the 10-year period; 315 had concomitant injuries, 87 had unresolved impairments, and 85 did not participate in the classification algorithm. The remaining 345 patients (216 men, 129 women) participated in the screening examination a mean of 6 weeks after the index injury. There were 199 subjects classified as noncopers and 146 as potential copers. Sixty-three of 88 potential copers successfully returned to preinjury activities without surgery, with 25 of these patients not undergoing anterior cruciate ligament reconstruction at the time of follow-up.
Conclusion: The classification algorithm is an effective tool for prospectively identifying individuals early after anterior cruciate ligament injury who want to pursue nonoperative care or must delay surgical intervention and have good potential to do so.
NAVIGATION
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13
May |
Gene Expression By UltravioletCategory: Genetics | Leave a Comment |
Imagine being able to control genetic expression by flipping a light switch. Researchers at North Carolina State University are using light-activated molecules to turn gene expression on and off. Their method enables greater precision when studying gene function, and could lead to targeted therapies for diseases like cancer…
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28
Mar |
Tiny DNA Reader Heralds Fast, Cheap SequencingCategory: Genetics | Leave a Comment |
The prospect of affordable personalized medicine using “genome sequencing while you wait” was brought a step closer this week when a study led by a University of Washington physics professor showed how a tiny nanoscale sensor can read the sequence of a single DNA molecule in a way that promises to be cheap and quick…
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28
Mar |
Fast, Cheap DNA Sequencing Feasible With Tiny ReaderCategory: Genetics | Leave a Comment |
Researchers have devised a nanoscale sensor to electronically read the sequence of a single DNA molecule, a technique that is fast and inexpensive and could make DNA sequencing widely available. The technique could lead to affordable personalized medicine, potentially revealing predispositions for afflictions such as cancer, diabetes or addiction…
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10
Feb |
Diagnosing Genetic Mutations - Virtual Tool, Pyromaker, Shows PromiseCategory: Genetics | Leave a Comment |
Cancer diagnosis and selecting the most appropriate treatment can be made easier by identifying genetic mutations through DNA sequencing…
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11
Jan |
Entire Human Genome Sequenced For $1,000Category: Genetics | Leave a Comment |
Life Technologies has launched the new Benchtop Ion Proton Sequencer, which can determine the entire human genome for $1,000, in as little as one day. Previously, it had taken the machine anywhere from weeks, and even months to sequence a human genome, and would cost between $5,000 and $10,000…
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20
Dec |
New DNA Detection Technique Demonstrated By Notre Dame ResearchersCategory: Genetics | Leave a Comment |
A team of researchers from the University of Notre Dame have demonstrated a novel DNA detection method that could prove suitable for many real-world applications. Physicists Carol Tanner and Steven Ruggiero led the team in the application of a new technique called laser transmission spectroscopy (LTS)…
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28
Nov |
DNA Barcoding Offers Quick, Cheap, Easy Way To Identify Species, Uncover FraudsCategory: Genetics | Leave a Comment |
As DNA “barcoding” technology becomes, quicker, cheaper and easier to develop, it is expanding rapidly into many areas from uncovering frauds such as mislabelled fish and unlisted ingredients in quack herbal medicines, to revealing ancient life-forms frozen in the Arctic permafrost, and preventing unwanted agricultural and forestry insect pests from crossing borders…
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24
Jul |
Successful Completion Of A Promising Next-Generation Sequencing ProjectCategory: Genetics | Leave a Comment |
Exonhit (Alternext: ALEHT), a biotech company focused on personalized medicine, and BGI, the world’s largest genome organization, are pleased to announce the successful completion of a project dedicated to expanding Exonhit’s Genome Wide SpliceArray™ to an additional strategic preclinical animal model species…
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23
Jul |
DNA Sequencing Technique Using Semiconductors Developed - Low Cost, Portable And ScalableCategory: Genetics | Leave a Comment |
Scientists at Ion Torrent Systems Inc. have created a DNA sequencing technique using semiconductors instead of the costly and complex optical technology. They say their device has a much lower cost, it is portable and can be upgraded (scalable). Their aim is to achieve the target price of $1,000 for a genome sequencing. Company founder, Dr…
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23
Jul |
DNA Sequencing Technique Using Semiconductors Developed - Low Cost, Portable And ScalableCategory: Genetics | Leave a Comment |
Scientists at Ion Torrent Systems Inc. have created a DNA sequencing technique using semiconductors instead of the costly and complex optical technology. They say their device has a much lower cost, it is portable and can be upgraded (scalable). Their aim is to achieve the target price of $1,000 for a genome sequencing. Company founder, Dr…